Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the
New England Journal of Medicine, report significant responses of cancers with microsatellite …

Immunotherapy has shown promising results in various types of cancers. Checkpoint
inhibitor drugs developed for cancer immunotherapy have been approved by the US Food …

Gastric cancer is one of the most aggressive malignancies, with limited treatment options in
both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic …

Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …

Muir-Torre syndrome is an autosomal-dominant skin condition of genetic origin,
characterised by tumours of the sebaceous gland or keratoacanthoma that are associated …

Lynch syndrome is the predisposition to visceral malignancies that are associated with
deleterious germline mutations in DNA mismatch repair genes, including MLH1, MSH2 …

In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the
spectrum of different forms of regulated cell death (RCD) has expanded dramatically with …

Nonmelanoma skin cancer (NMSC) is the most frequently diagnosed malignancy in
humans, representing a broad range of cutaneous tumors. Keratinocyte carcinomas …

Mismatch repair protein immunohistochemistry is a widely used method for detecting
patients at risk for Lynch syndrome. Recent data suggest that a two-antibody panel …

BACKGROUND. Sebaceous tumors of the skin occurring in association with an internal
malignancy characterize Muir‐Torre syndrome (MTS), a variant of hereditary nonpolyposis …