Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

The past two decades in research has revealed the importance of leucine-rich repeat kinase
2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families …

Parkinson's disease (PD) is a growing burden worldwide, and there is no reliable biomarker
used in clinical routines to date. Cerebrospinal fluid (CSF) is routinely collected in patients …

Genetic variation around the LRRK2 gene affects risk of both familial and sporadic
Parkinson's disease (PD). However, the biological functions of LRRK2 remain incompletely …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Genetic variation at the leucine-rich repeat kinase 2 (LRRK2) locus contributes to an
enhanced risk of familial and sporadic Parkinson's disease. Previous data have …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic
cause of Parkinson's disease (PD), with growing importance also for Crohn's disease and …

An emerging picture suggests that glial cells' loss of beneficial roles or gain of toxic functions
can contribute to neurodegenerative conditions. Among glial cells, microglia and astrocytes …

Protein coding mutations in leucine‐rich repeat kinase 2 (LRRK2) cause familial Parkinson's
disease (PD), and noncoding variations around the gene increase the risk of developing …

Cells maintain optimal levels of lysosome degradative activity to protect against pathogens,
clear waste, and generate nutrients. Here, we show that LRRK2, a protein that is tightly …