Increases in the incidence and mortality due to the major invasive fungal infections such as
aspergillosis, candidiasis and cryptococcosis caused by the species of Aspergillus, Candida …

Calcineurin signaling plays diverse roles in fungi in regulating stress responses,
morphogenesis and pathogenesis. Although calcineurin signaling is conserved among …

Calcineurin is a highly conserved serine-threonine specific protein phosphatase and was
named based on its discovery as a calcium-and calmodulin-binding protein that is highly …

Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal
pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels …

Cryptococcosis is an infectious disease of global significance for which new therapies are
needed. Repurposing previously developed drugs for new indications can expedite the …

Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C …

Calcineurin (CaN) activation is critically involved in the regulation of spine morphology in
response to oligomeric amyloid-β (Aβ) as well as in synaptic plasticity in normal memory, but …

The pathogenic yeast Cryptococcus gattii, which is causing an outbreak in the Pacific
Northwest region of North America, causes life-threatening pulmonary infections and …

The pathogenic fungi C andida albicans, A spergillus fumigatus, and C ryptococcus
neoformans are an increasing cause of human mortality, especially in immunocompromised …

White-rot fungi secrete numerous enzymes involved in lignocellulose degradation. However,
the secretory mechanisms or pathways, including protein synthesis, folding, modification …