Concerning the reported biological activities of bis-heterocycles, hydantoin, and
thiohydantoin moieties, a series of some new bis-hydantoins/thiohydantoins have been …

Schistosomiasis is a devastating worldwide widespread tropical disease that currently
affects more than 230 million people, making it an issue of great socioeconomic and public …

Schistosomiasis is considered a serious public health problem in 78 countries and territories
located in Africa, Asia and America and it is estimated in more than 249 million people …

Resumo Hydantoin (imidazolidine-2, 4-dione) is a 2, 4-diketotetrahydroimidazole
discovered by Baeyer in 1861. Thiohydantoins and derivatives were prepared, having …

A novel series of S‐alkylated, N‐alkylated, and N‐glycosylated 2‐thiohydantoin derivatives
were synthesized via the reaction of (E)‐5‐(arylidene)‐1‐phenyl‐2‐thiohydantoins 5a–d …

The only drug available for treating schistosomiasis is praziquantel, however there are
already reports of resistance to its use in treatment, making it necessary to search and …

Schistosomiasis is a disease caused by helminthes of the genus Schistosoma, which
threatens approximately 207 million people worldwide. Recently, strains of Schistosoma …

A one-pot three-component sequential synthetic protocol produces structurally and
biologically important phthalidyl fused spiro N, N′-disubstituted thiohydantoins from readily …

The study aimed to conduct in vitro biological assessments of hydantoin and thiohydantoin
compounds against mature Schistosoma mansoni worms, evaluate their cytotoxic effects …

The main pathology associated with Schistosomiasis mansoni is granulomatous
inflammation that may develop into hepatosplenic disease with fibrosis and …