Roles of the microbiota of the female reproductive tract in gynecological and reproductive health

B Zhu, Z Tao, L Edupuganti, MG Serrano… - … and Molecular Biology …, 2022 - Am Soc Microbiol
The microbiome of the female reproductive tract defies the convention that high biodiversity
is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous …

The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis

U Gudnadottir, JW Debelius, J Du, LW Hugerth… - Scientific reports, 2022 - nature.com
Preterm birth is a major cause of neonatal morbidity and mortality worldwide. Increasing
evidence links the vaginal microbiome to the risk of spontaneous preterm labour that leads …

Inflammatory bowel disease treatments and predictive biomarkers of therapeutic response

DA Elhag, M Kumar, M Saadaoui, AK Akobeng… - International journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the
gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and …

Infections and pregnancy: effects on maternal and child health

M Kumar, M Saadaoui, S Al Khodor - Frontiers in Cellular and …, 2022 - frontiersin.org
Pregnancy causes physiological and immunological adaptations that allow the mother and
fetus to communicate with precision in order to promote a healthy pregnancy. At the same …

The female reproductive tract microbiotas, inflammation, and gynecological conditions

M Gholiof, E Adamson-De Luca… - Frontiers in Reproductive …, 2022 - frontiersin.org
The intricate interactions between the host cells, bacteria, and immune components that
reside in the female reproductive tract (FRT) are essential in maintaining reproductive tract …

Vaginal microbiome: considerations for reproductive health

C Chopra, I Bhushan, M Mehta, T Koushal… - Future …, 2022 - Taylor & Francis
The microbial communities are an indispensable part of the human defense system and
coexist with humans as symbionts, contributing to the metabolic functions and immune …

[HTML][HTML] Microbiome preterm birth DREAM challenge: crowdsourcing machine learning approaches to advance preterm birth research

JL Golob, TT Oskotsky, AS Tang, A Roldan… - Cell Reports …, 2024 - cell.com
Every year, 11% of infants are born preterm with significant health consequences, with the
vaginal microbiome a risk factor for preterm birth. We crowdsource models to predict (1) …

COVID-19 infection during pregnancy: risk of vertical transmission, fetal, and neonatal outcomes

M Saadaoui, M Kumar, S Al Khodor - Journal of personalized medicine, 2021 - mdpi.com
The COVID-19 pandemic is a worldwide, critical public health challenge and is considered
one of the most communicable diseases that the world had faced so far. Response and …

Microbial dysbiosis tunes the immune response towards allergic disease outcomes

T Augustine, M Kumar, S Al Khodor… - Clinical Reviews in …, 2023 - Springer
The hygiene hypothesis has been popularized as an explanation for the rapid increase in
allergic disease observed over the past 50 years. Subsequent epidemiological studies have …

Predicting preterm birth through vaginal microbiota, cervical length, and WBC using a machine learning model

S Park, J Moon, N Kang, YH Kim, YA You… - Frontiers in …, 2022 - frontiersin.org
An association between the vaginal microbiome and preterm birth has been reported.
However, in practice, it is difficult to predict premature birth using the microbiome because …