Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to
manage this disease. However, the current standard of care does not provide satisfactory …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

Mechanical injury is the most important risk factor in osteoarthritis (OA) development.
Although once considered a passive disease of mechanical attrition, injury drives active …

Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in
nature and associated with daily activities such as walking and climbing stairs. Piezo2 has …

Although bone is continually being remodeled and ultimately declines with aging, little is
known whether similar changes occur in the sensory and sympathetic nerve fibers that …

Despite an increasing burden of osteoarthritis in developed societies, target discovery has
been slow and there are currently no approved disease-modifying osteoarthritis drugs. This …

Objective The role of inflammation in structural and symptomatic osteoarthritis (OA) remains
unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for …

Abstract Purpose of Review Osteoarthritis (OA) is the most common form of arthritis and a
major source of pain and disability worldwide. OA-associated pain is usually refractory to …

Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …