[HTML][HTML] Small angle X-ray diffraction as a tool for structural characterization of muscle disease
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …
structural information from striated muscle fibers under hydrated physiological conditions …
Exploring the connection between relaxed myosin states and the Anrep effect
V Sequeira, C Maack, GH Reil, JC Reil - Circulation Research, 2024 - Am Heart Assoc
The Anrep effect is an adaptive response that increases left ventricular contractility following
an acute rise in afterload. Although the mechanistic origin remains undefined, recent …
an acute rise in afterload. Although the mechanistic origin remains undefined, recent …
A research study on new energy brand users based on principal component analysis (PCA) and fusion target planning model for sustainable environment of smart …
T Wang, F Zhang, H Gu, H Hu, M Kaur - Sustainable Energy Technologies …, 2023 - Elsevier
The preservation of green environment is inevitable in order to reduce the carbon emissions
from the atmosphere. The development of infrastructure, vehicle technology and global …
from the atmosphere. The development of infrastructure, vehicle technology and global …
Cardiac myosin filaments are directly regulated by calcium
Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …
[HTML][HTML] NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy
N Ranu, J Laitila, HF Dugdale, J Mariano… - Acta neuropathologica …, 2022 - Springer
Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle
disorders. NM is often associated with mutations in the NEB gene. Even though the exact …
disorders. NM is often associated with mutations in the NEB gene. Even though the exact …
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function
Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …
[HTML][HTML] Muscle mechanics and thick filament activation: an emerging two-way interaction for the vertebrate striated muscle fine regulation
L Marcucci - International Journal of Molecular Sciences, 2023 - mdpi.com
Contraction in striated muscle is classically described as regulated by calcium-mediated
structural changes in the actin-containing thin filaments, which release the binding sites for …
structural changes in the actin-containing thin filaments, which release the binding sites for …
The structural OFF and ON states of myosin can be decoupled from the biochemical super-and disordered-relaxed states
There is a growing awareness that both thick-filament and classical thin-filament regulations
play central roles in modulating muscle contraction. Myosin ATPase assays have …
play central roles in modulating muscle contraction. Myosin ATPase assays have …
[HTML][HTML] The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation
Structural and functional studies of heart muscle are important to gain insights into the
physiological bases of cardiac muscle contraction and the pathological bases of heart …
physiological bases of cardiac muscle contraction and the pathological bases of heart …
Mechanisms of sarcomere protein mutation-induced cardiomyopathies
DY Barefield, A Alvarez-Arce, KN Araujo - Current cardiology reports, 2023 - Springer
Abstract Purpose of Review The pace of identifying cardiomyopathy-associated mutations
and advances in our understanding of sarcomere function that underlies many …
and advances in our understanding of sarcomere function that underlies many …