Control of tissue development by morphogens
Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …
tissues to provide spatial information and control properties such as cell fate and tissue …
Morphogen rules: design principles of gradient-mediated embryo patterning
The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
Species-specific pace of development is associated with differences in protein stability
T Rayon, D Stamataki, R Perez-Carrasco… - Science, 2020 - science.org
INTRODUCTION What determines the pace of embryonic development? Although the
molecular and cellular mechanisms of many developmental processes are evolutionarily …
molecular and cellular mechanisms of many developmental processes are evolutionarily …
[PDF][PDF] Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord
The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …
tube determines the identity of neural progenitors and the function and physiology of the …
[HTML][HTML] Establishing neuronal diversity in the spinal cord: a time and a place
The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …
arranged in characteristic positions. During development, these different types of neurons …
Modeling ALS with motor neurons derived from human induced pluripotent stem cells
Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …
Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features
The spinal cord receives input from peripheral sensory neurons and controls motor output by
regulating muscle innervating motor neurons. These functions are carried out by neural …
regulating muscle innervating motor neurons. These functions are carried out by neural …
A shared transcriptional code orchestrates temporal patterning of the central nervous system
The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate
nervous system are incompletely understood. Here, we provide evidence of a global …
nervous system are incompletely understood. Here, we provide evidence of a global …
Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders
Genetic variants in chromatin regulators are frequently found in neurodevelopmental
disorders, but their effect in disease etiology is rarely determined. Here, we uncover and …
disorders, but their effect in disease etiology is rarely determined. Here, we uncover and …
Decoding of position in the developing neural tube from antiparallel morphogen gradients
Like many developing tissues, the vertebrate neural tube is patterned by antiparallel
morphogen gradients. To understand how these inputs are interpreted, we measured …
morphogen gradients. To understand how these inputs are interpreted, we measured …