The regulative capability of single cells to give rise to all primary embryonic lineages is
termed pluripotency. Observations of fluctuating gene expression and phenotypic …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Understanding lineage specification during human pre-implantation development is a
gateway to improving assisted reproductive technologies and stem cell research. Here we …

Pluripotency denotes the flexible capacity of single cells to give rise to all somatic lineages
and typically also the germline. Mouse ES cells and post‐implantation epiblast‐derived stem …

Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive
cues. Release from this ground state in minimal conditions offers a system for delineating …

The mouse embryo is the canonical model for mammalian preimplantation development.
Recent advances in single cell profiling allow detailed analysis of embryogenesis in other …

During embryonic development, naive pluripotent epiblast cells transit to a formative state.
The formative epiblast cells form a polarized epithelium, exhibit distinct transcriptional and …

Naive pluripotent stem cells have the highest developmental potential but their in vivo
existence in the blastocyst is transient. Here we report a blastocyst motif substrate for the in …

Human naïve pluripotent stem cells (PSCs) share features with the pre-implantation epiblast.
They therefore provide an unmatched opportunity for characterising the developmental …

In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative
pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells …