The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to
either signal through intracellular targets or to activate a family of specific G-protein-coupled …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Background Inhibition of sphingosine kinase 1 (SphK1), which catalyzes bioactive lipid
sphingosine-1–phosphate (S1P), attenuates NLRP3 inflammasome activation. S1P exerts …

With the sudden outbreak of COVID-19 patient worldwide and associated mortality, it is
critical to come up with an effective treatment against SARS-CoV-2. Studies suggest that …

The cellular membranes of Trypanosoma cruzi, like all eukaryotes, contain varying amounts
of phospholipids, sphingolipids, neutral lipids and sterols. A multitude of pathways exist for …

Abstract IL-6, IL-17, IL-23 and IL-1β are the crucial cytokines controlling inflammatory and
immune response during L. major infection. During cutaneous leishmaniasis, an important T …

Raman spectroscopy is a rapid qualitative and quantitative technique that allows the
simultaneous determination of several components in biological fluids. This methodology …

Visceral leishmaniasis (VL) is caused by a protozoan parasite, Leishmania donovani (L.
donovani). It affects around 1–2 million people around the world annually. There is an …

Cholesterol reduction by intracellular protozoan parasite Leishmania donovani, causative
agent of leishmaniasis, impairs antigen presentation, pro-inflammatory cytokine secretion …

There has been increased interest in using metagenomic next-generation sequencing as an
unbiased approach for diagnosing infectious diseases. We describe a 61-year-old man on …