Immune-checkpoint inhibitors and chimeric antigen receptor (CAR) T cells are
revolutionizing oncology and haematology practice. With these and other immunotherapies …

Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the
discovery of the potent anti-tumour activities of several pro-inflammatory cytokines in animal …

Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment …

Immunotherapy, where the patient's own immune system is exploited to eliminate tumor
cells, has become one of the most prominent new cancer treatment options in the last …

The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking
cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal …

While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity,
and propensity to amplify Treg cells are major barriers that prevent IL-2 from being widely …

The dysregulated expression of immune checkpoint molecules enables cancer cells to
evade immune destruction. While blockade of inhibitory immune checkpoints like PD-L1 …

Impaired immune function has been implicated in the declining health and higher incidence
of cancer in the elderly. However, age-related changes to immunity are not completely …

Abstract Purpose: Myeloid suppressor (Gr-1+/CD11b+) cells accumulate in the spleens of
tumor-bearing mice where they contribute to immunosuppression by inhibiting the function …

The costimulatory effects of CD27 on T lymphocyte effector function and memory formation
has been confined to evaluations in mouse models, in vitro human cell culture systems, and …