Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health

BP O'Gara, L Gao, ER Marcantonio… - Anesthesiology, 2021 - pubs.asahq.org
The prevention of perioperative neurocognitive disorders is a priority for patients, families,
clinicians, and researchers. Given the multiple risk factors present throughout the …

Postoperative outcomes in older surgical patients with preoperative cognitive impairment: A systematic review and meta-analysis

L Chen, E Au, A Saripella, P Kapoor, E Yan… - Journal of Clinical …, 2022 - Elsevier
Study objective To determine the effect of cognitive impairment (CI) and dementia on
adverse outcomes in older surgical patients. Design A systematic review and meta-analysis …

Outcomes of a delirium prevention program in older persons after elective surgery: a stepped-wedge cluster randomized clinical trial

F Deeken, A Sánchez, MA Rapp, M Denkinger… - JAMA …, 2022 - jamanetwork.com
Importance Delirium significantly worsens elective surgery outcomes and costs. Delirium risk
is highest in elderly populations, whose surgical health care resource consumption (50%) …

Cognitive decline associated with anesthesia and surgery in older patients

S Vacas, DJ Cole, M Cannesson - Jama, 2021 - jamanetwork.com
In the last decade, the population aged 65 years and older increased by 34.2% in the US
and now accounts for a disproportionatenumberofsurgicalprocedur…. Amongthese patients …

Economic burden of postoperative neurocognitive disorders among US medicare patients

MD Boone, B Sites, FM von Recklinghausen… - JAMA network …, 2020 - jamanetwork.com
Importance Postoperative neurocognitive disorders (PNDs) after surgical procedures are
common and may be associated with increased health care expenditures. Objective To …

Acute peri‐operative neurocognitive disorders: a narrative review

L Evered, K Atkins, B Silbert, DA Scott - Anaesthesia, 2022 - Wiley Online Library
Peri‐operative neurocognitive disorders are the most common complication experienced by
older individuals undergoing anaesthesia and surgery. Peri‐operative neurocognitive …

Postoperative delirium and neurocognitive disorders

A Migirov, P Chahar, K Maheshwari - Current opinion in critical …, 2021 - journals.lww.com
A spectrum of NCD exists in surgical patients ranging from postoperative delirium, delayed
neurocognitive recovery, and POCD. Identification of patients at-risk for developing NCD can …

[HTML][HTML] Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team

CJ Peden, TR Miller, SG Deiner, RG Eckenhoff… - British Journal of …, 2021 - Elsevier
Delirium and postoperative neurocognitive disorder are the commonest perioperative
complications in patients more than 65 yr of age. However, data suggest that we often fail to …

Frailty is associated with postoperative delirium but not with postoperative cognitive decline in older noncardiac surgery patients

E Mahanna-Gabrielli, K Zhang, FE Sieber… - Anesthesia & …, 2020 - journals.lww.com
BACKGROUND: Postoperative cognitive dysfunction (POCD) and delirium are the most
common perioperative cognitive complications in older adults undergoing surgery. A recent …

Modulatory dynamics mark the transition between anesthetic states of unconsciousness

E Adam, O Kwon, KA Montejo… - Proceedings of the …, 2023 - National Acad Sciences
Unconsciousness maintained by GABAergic anesthetics, such as propofol and sevoflurane,
is characterized by slow-delta oscillations (0.3 to 4 Hz) and alpha oscillations (8 to 14 Hz) …