Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

This paper considers psychotic symptoms in terms of false inferences or beliefs. It is based
on the notion that the brain is an inference machine that actively constructs hypotheses to …

Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent
psychosocial disability in affected individuals. Although studies of schizophrenia have …

Classic serotonergic hallucinogens or psychedelics produce an altered states of
consciousness (ASC) that is characterized by profound alterations in sensory perception …

There is converging evidence that high doses of hallucinogenic drugs can produce
significant alterations of self-experience, described as the dissolution of the sense of self …

The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …

Hallucinations, a cardinal feature of psychotic disorders such as schizophrenia, are known
to depend on excessive striatal dopamine. However, an underlying cognitive mechanism …

Interest in the therapeutic potential of psychedelic substances has recently resumed. During
an early phase of human psychedelic research, their therapeutic application in different …

Discriminating subjects at clinical high risk (CHR) for psychosis who will develop psychosis
from those who will not is a prerequisite for preventive treatments. However, it is not yet …

Background: Research on psilocybin has become increasingly popular during the current
psychedelic renaissance, which began in the early 1990s. Psilocybin's effects on mental …