The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Three embryonic tissue sources—the neural ectoderm, the surface ectoderm, and the
periocular mesenchyme—contribute to the formation of the mammalian eye. For this reason …

Organogenesis of the eye is a multistep process that starts with the formation of optic
vesicles followed by invagination of the distal domain of the vesicles and the overlying lens …

The retinal pigment epithelium (RPE) is a simple epithelium interposed between the neural
retina and the choroid. Although only 1 cell-layer in thickness, the RPE is a virtual …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

The generation of a functional nervous system involves a multitude of steps that are
controlled by just a few families of extracellular signaling molecules. Among these, the …

This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …

The cilium is the site of function for a variety of membrane receptors, enzymes and signal
transduction modules crucial for a spectrum of cellular processes. Through targeted …

The self-formation of retinal tissue from pluripotent stem cells generated a tremendous
promise for developing new therapies of retinal degenerative diseases, which previously …

A unique feature of humans is the complexity of our central nervous system. A fully functional
brain requires that billions of neurons make specific contacts in a highly coordinated way, an …