Significance: The immune system plays a central role in orchestrating the tissue healing
process. Hence, controlling the immune system to promote tissue repair and regeneration is …

Pregnancy involves a complex interplay between maternal neuroendocrine and
immunological systems in order to establish and sustain a growing fetus. It is thought that the …

The severity of tissue injury in burn wounds from associated inflammatory and immune
sequelae presents a significant clinical management challenge. Among various biophysical …

Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

Immune regulation by cytokines is crucial in maintaining immune homeostasis, promoting
responses to infection, resolving inflammation, and promoting immunological memory …

Transforming growth factor beta (TGFβ) is named for the function it was originally discovered
to perform-transformation of normal cells into aggressively growing malignant cells. It …

White adipose tissue (WAT) mass is determined by adipocyte size and number. While
adipocytes are continuously turned over, the mechanisms controlling fat cell number in WAT …

TGF-β family members are multipotent cytokines that are involved in many cellular
processes, including cell differentiation, organ development, wound healing and immune …

Purpose: Interleukin (IL)-1α/IL-1β and transforming growth factor (TGF) β1/TGFβ2 have both
been promoted as “master regulators” of the corneal wound healing response due to the …

TGF-β1,-β2, and-β3 are small, secreted signaling proteins. They share 71–80% sequence
identity and signal through the same receptors, yet the isoform-specific null mice have …