Cancer immune escape: MHC expression in primary tumours versus metastases
F Garrido, N Aptsiauri - Immunology, 2019 - Wiley Online Library
Tumours can escape T‐cell responses by losing major histocompatibility complex
(MHC)/human leucocyte antigen (HLA) class I molecules. In the early stages of cancer …
(MHC)/human leucocyte antigen (HLA) class I molecules. In the early stages of cancer …
Does the immune system naturally protect against cancer?
A Corthay - Frontiers in immunology, 2014 - frontiersin.org
The importance of the immune system in conferring protection against pathogens like
viruses, bacteria, and parasitic worms is well established. In contrast, there is a long-lasting …
viruses, bacteria, and parasitic worms is well established. In contrast, there is a long-lasting …
MHC class I antigens, immune surveillance, and tumor immune escape
A Garcia‐Lora, I Algarra… - Journal of cellular …, 2003 - Wiley Online Library
Oncogenic transformation in human and experimental animals is not necessarily followed by
the appearance of a tumor mass. The immune system of the host can recognize tumor …
the appearance of a tumor mass. The immune system of the host can recognize tumor …
HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy
P Anderson, N Aptsiauri, F Ruiz-Cabello… - Cellular & molecular …, 2021 - nature.com
T cell-mediated immune therapies have emerged as a promising treatment modality in
different malignancies including colorectal cancer (CRC). However, only a fraction of …
different malignancies including colorectal cancer (CRC). However, only a fraction of …
Therapeutic potential and challenges of natural killer cells in treatment of solid tumors
A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
“Hard” and “soft” lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy
The ability of cancer cells to escape from the natural or immunotherapy‐induced antitumor
immune response is often associated with alterations in the tumor cell surface expression of …
immune response is often associated with alterations in the tumor cell surface expression of …
Targeting loss of heterozygosity for cancer-specific immunotherapy
MS Hwang, BJ Mog, J Douglass… - Proceedings of the …, 2021 - National Acad Sciences
Developing therapeutic agents with potent antitumor activity that spare normal tissues
remains a significant challenge. Clonal loss of heterozygosity (LOH) is a widespread and …
remains a significant challenge. Clonal loss of heterozygosity (LOH) is a widespread and …
Rejection versus escape: the tumor MHC dilemma
Most tumor cells derive from MHC-I-positive normal counterparts and remain positive at
early stages of tumor development. T lymphocytes can infiltrate tumor tissue, recognize and …
early stages of tumor development. T lymphocytes can infiltrate tumor tissue, recognize and …
Genetic evolution of T-cell resistance in the course of melanoma progression
A Sucker, F Zhao, B Real, C Heeke, N Bielefeld… - Clinical Cancer …, 2014 - AACR
Purpose: CD8+ T lymphocytes can kill autologous melanoma cells, but their activity is
impaired when poorly immunogenic tumor phenotypes evolve in the course of disease …
impaired when poorly immunogenic tumor phenotypes evolve in the course of disease …
MHC antigens and tumor escape from immune surveillance
F Garrido, I Algarra - 2001 - Elsevier
Publisher Summary The chapter presents that the primary and metastatic tumor cell growth
results from the development of sophisticated molecular and biological mechanisms that …
results from the development of sophisticated molecular and biological mechanisms that …