Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

W Rungratanawanich, Y Qu, X Wang… - … & molecular medicine, 2021 - nature.com
Advanced glycation end products (AGEs) are potentially harmful and heterogeneous
molecules derived from nonenzymatic glycation. The pathological implications of AGEs are …

Receptor for advanced glycation end products (RAGE) and mechanisms and therapeutic opportunities in diabetes and cardiovascular disease: insights from human …

L Egaña-Gorroño, R López-Díez, G Yepuri… - Frontiers in …, 2020 - frontiersin.org
Obesity and diabetes are leading causes of cardiovascular morbidity and mortality. Although
extensive strides have been made in the treatments for non-diabetic atherosclerosis and its …

Obesity may accelerate the aging process

V Salvestrini, C Sell, A Lorenzini - Frontiers in endocrinology, 2019 - frontiersin.org
Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

Dietary sugars and endogenous formation of advanced glycation endproducts: emerging mechanisms of disease

M Aragno, R Mastrocola - Nutrients, 2017 - mdpi.com
The rapid increase in metabolic diseases, which occurred in the last three decades in both
industrialized and developing countries, has been related to the rise in sugar-added foods …

Advanced glycation end products: building on the concept of the “common soil” in metabolic disease

HH Ruiz, R Ramasamy, AM Schmidt - Endocrinology, 2020 - academic.oup.com
The role of advanced glycation end products (AGEs) in promoting and/or exacerbating
metabolic dysregulation is being increasingly recognized. AGEs are formed when reducing …

Diabetes mellitus and cardiovascular disease: Emerging therapeutic approaches

AM Schmidt - Arteriosclerosis, thrombosis, and vascular biology, 2019 - Am Heart Assoc
Cardiovascular disease remains a leading cause of morbidity and mortality in people with
types 1 or 2 diabetes mellitus. Although beneficial roles for strict control of hyperglycemia …

[HTML][HTML] Metabolic stress-induced joint inflammation and osteoarthritis

A Courties, O Gualillo, F Berenbaum, J Sellam - Osteoarthritis and cartilage, 2015 - Elsevier
Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them,
obesity has a major impact on both loading and non-loading joints. Mechanical overload …

Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

Y Li, C Chen, Y Ma, J Xiao, G Luo, Y Li, D Wu - Life sciences, 2019 - Elsevier
Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female
infertility around the world. It is no longer considered simply as a disease of ovary. Now …

The modern western diet rich in advanced glycation end-products (AGEs): An overview of its impact on obesity and early progression of renal pathology

A Bettiga, F Fiorio, F Di Marco, F Trevisani, A Romani… - Nutrients, 2019 - mdpi.com
Advanced glycation end-products (AGEs) are an assorted group of molecules formed
through covalent bonds between a reduced sugar and a free amino group of proteins, lipids …

Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice

MB Manigrasso, P Rabbani, L Egaña-Gorroño… - Science translational …, 2021 - science.org
The macro-and microvascular complications of type 1 and 2 diabetes lead to increased
disease severity and mortality. The receptor for advanced glycation end products (RAGE) …