Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Management of infants at risk for group B streptococcal disease

KM Puopolo, R Lynfield, JJ Cummings, I Hand… - …, 2019 - publications.aap.org
Group B streptococcal (GBS) infection remains the most common cause of neonatal early-
onset sepsis and a signiicant cause of late-onset sepsis among young infants …

Potential for maternally administered vaccine for infant group B streptococcus

SA Madhi, AS Anderson, J Absalon… - … England Journal of …, 2023 - Mass Medical Soc
Background Natural history studies have correlated serotype-specific anti–capsular
polysaccharide (CPS) IgG in newborns with a reduced risk of group B streptococcal disease …

Estimates of the burden of group B streptococcal disease worldwide for pregnant women, stillbirths, and children

AC Seale, F Bianchi-Jassir, NJ Russell… - Clinical infectious …, 2017 - academic.oup.com
Background We aimed to provide the first comprehensive estimates of the burden of group B
Streptococcus (GBS), including invasive disease in pregnant and postpartum women, fetal …

Group B streptococcal colonization, molecular characteristics, and epidemiology

S Shabayek, B Spellerberg - Frontiers in microbiology, 2018 - frontiersin.org
Streptococcus agalactiae or group B streptococcus (GBS) is a leading cause of serious
neonatal infections. GBS is an opportunistic commensal constituting a part of the intestinal …

Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

JR Zunt, NJ Kassebaum, N Blake, L Glennie… - The Lancet …, 2018 - thelancet.com
Background Acute meningitis has a high case-fatality rate and survivors can have severe
lifelong disability. We aimed to provide a comprehensive assessment of the levels and …

Safety and immunogenicity of a novel hexavalent group B streptococcus conjugate vaccine in healthy, non-pregnant adults: a phase 1/2, randomised, placebo …

J Absalon, N Segall, SL Block, KJ Center… - The Lancet Infectious …, 2021 - thelancet.com
Summary Background Group B streptococcus (GBS) is a major cause of invasive disease in
young infants. Infants born to women with sufficient pre-existing anti-GBS capsular IgG …

Epidemiology of invasive group B streptococcal infections among nonpregnant adults in the United States, 2008-2016

LKF Watkins, L McGee, SJ Schrag, B Beall… - JAMA internal …, 2019 - jamanetwork.com
Importance Group BStreptococcus (GBS) is an important cause of invasive bacterial
disease. Previous studies have shown a substantial and increasing burden of GBS …

Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants

T Tapiainen, P Koivusaari, L Brinkac, HA Lorenzi… - Scientific reports, 2019 - nature.com
Abstract Altogether, 20–30% of women receive intrapartum antibiotic prophylaxis (IAP) to
prevent sepsis in infants and 2–5% of newborn infants receive antibiotics due to suspected …

The Impact of IgG transplacental transfer on early life immunity

GG Fouda, DR Martinez, GK Swamy, SR Permar - Immunohorizons, 2018 - journals.aai.org
Pediatric vaccines have significantly reduced infectious disease–related infant mortality, but
as protective immunity often requires several infant vaccine doses, maternally acquired Abs …