Ample evidence exists in support of the potent anti-inflammatory properties of statins. In cell
studies and animal models statins exert beneficial cardiovascular effects. By inhibiting …

The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) has overwhelmed healthcare systems requiring the rapid development of …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …

Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …

CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF),
is one of the founding members of the CCN family of matricellular proteins. Extensive …

Chronic inflammation enhances the detrimental role of dyslipidaemia during atherogenesis.
Statins are among the most effective anti-atherosclerotic medications, being able to impact …

Fibrosis is a pathological repair process common among organs, that responds to tissue
damage by replacement with non-functional connective tissue. Despite the widespread …