Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

H Luo, CT Vong, H Chen, Y Gao, P Lyu, L Qiu, M Zhao… - Chinese medicine, 2019 - Springer
Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

Advancement of sialyltransferase inhibitors: therapeutic challenges and opportunities

R Szabo, D Skropeta - Medicinal Research Reviews, 2017 - Wiley Online Library
Hypersialylation of tumor cell surface proteins along with a marked upregulation of
sialyltransferase (ST) activity is a well‐established hallmark of cancer. Due to the critical role …

Triptolide attenuates myocardial ischemia/reperfusion injuries in rats by inducing the activation of Nrf2/HO-1 defense pathway

H Yu, L Shi, S Zhao, Y Sun, Y Gao, Y Sun… - Cardiovascular …, 2016 - Springer
Triptolide is a bioactive component of Chinese herbal plant Tripterygium wilfordii Hook F that
has recently been noted to attenuate hepatic and cerebral ischemia/reperfusion (I/R) injuries …

Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI‐3 cells in vitro and promoting immune responses in WEHI‐3 generated leukemia mice …

SF Chan, YY Chen, JJ Lin, CL Liao… - Environmental …, 2017 - Wiley Online Library
Triptolide, a traditional Chinese medicine, obtained from Tripterygium wilfordii Hook F, has
anti‐inflammatory, antiproliferative, and proapoptotic properties. We investigated the …

Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells

H Zhou, Y Liu, C Wang, L Liu, H Wang, Y Zhang… - Journal of Experimental …, 2018 - Springer
Abstract Background Epstein-Barr virus (EBV) is widely found in nasopharyngeal carcinoma
(NPC) tissue and associated with poor prognosis of patients. EBV nuclear antigen 1 …

Triptolide decreases cell proliferation and induces cell death in triple negative MDA-MB-231 breast cancer cells

E Varghese, SM Samuel, S Varghese, S Cheema… - Biomolecules, 2018 - mdpi.com
Triple negative breast cancers (TNBCs) do not respond to conventional estrogen
receptor/progesterone receptor/human epidermal growth factor receptor-2 targeted …

[图书][B] Cancer inhibitors from Chinese natural medicines

JP Xu - 2016 - taylorfrancis.com
Nature is an attractive source of therapeutic and preventive compounds, and with such
chemical diversity found in millions of species of plants, over 60% of currently used …

Antibiotic drug tigecycline reduces neuroblastoma cells proliferation by inhibiting Akt activation in vitro and in vivo

X Zhong, E Zhao, C Tang, W Zhang, J Tan, Z Dong… - Tumor Biology, 2016 - Springer
As the first member of glycylcycline bacteriostatic agents, tigecycline is approved as a novel
expanded-spectrum antibiotic, which is clinically available. However, accumulating …

Cloning and Characterisation of the Gene Encoding 3-Hydroxy-3-Methylglutaryl-CoA Synthase in Tripterygium wilfordii

YJ Liu, YJ Zhao, M Zhang, P Su, XJ Wang, XN Zhang… - Molecules, 2014 - mdpi.com
Tripterygium wilfordii is a traditional Chinese medical plant used to treat rheumatoid arthritis
and cancer. The main bioactive compounds of the plant are diterpenoids and triterpenoids. 3 …

1H NMR-Based Metabolomics Reveals the Antitumor Mechanisms of Triptolide in BALB/c Mice Bearing CT26 Tumors

C Li, Z Li, T Zhang, P Wei, N Li, W Zhang… - Frontiers in …, 2019 - frontiersin.org
Triptolide, the main active ingredient in Tripterygium wilfordii Hook. f.(Celastraceae), has
shown promising effects against a variety of tumors. However, the molecular …