Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

This article is part of a Minifocus on collective cell migration. For further reading, please see
related articles: ʻMechanisms of collective cell migration at a glanceʼ by Olga Ilina and …

A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to
changes in intracellular Ca2+ levels. A unique class of these proteins—annexins—can bind …

Abstract Treatment of inflammatory diseases today is largely based on interrupting the
synthesis or action of mediators that drive the host's response to injury. Non-steroidal anti …

Annexins are a well-known multigene family of Ca2+-regulated phospholipid-binding and
membrane-binding proteins. Recent work employing annexin-knockdown or-knockout …

N-formyl peptide receptors (FPRs) are critical regulators of host defense in phagocytes and
are also expressed in epithelia. FPR signaling and function have been extensively studied …

There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely
by inhibiting the function of nuclear factor κB (NFκB) and consequently the transcription of …

Inflammation is the body's way of defending itself against noxious stimuli and pathogens.
Under normal circumstances, the body is able to eliminate the insult and subsequently …

Cardiovascular disease (CVD) remains a leading cause of mortality and morbidity
worldwide. Numerous therapies are currently under investigation to improve pathological …