Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis
EA Merkel, LS Mohan, K Shi, E Panah… - The Lancet Child & …, 2019 - thelancet.com
Paediatric melanoma is rare and challenging to diagnose. The three subtypes are Spitzoid
melanoma, melanoma arising in a congenital melanocytic nevus, and conventional (also …
melanoma, melanoma arising in a congenital melanocytic nevus, and conventional (also …
Phase I clinical trial of ipilimumab in pediatric patients with advanced solid tumors
MS Merchant, M Wright, K Baird, LH Wexler… - Clinical Cancer …, 2016 - AACR
Purpose: Ipilimumab is a first-in-class immune checkpoint inhibitor approved for treatment of
metastatic melanoma but not studied in children until this phase I protocol. Experimental …
metastatic melanoma but not studied in children until this phase I protocol. Experimental …
Pediatric melanoma: incidence, treatment, and prognosis
FK Saiyed, EC Hamilton, MT Austin - Pediatric Health, Medicine …, 2017 - Taylor & Francis
The purpose of this review is to outline recent advancements in diagnosis, treatment, and
prevention of pediatric melanoma. Despite the recent decline in incidence, it continues to be …
prevention of pediatric melanoma. Despite the recent decline in incidence, it continues to be …
Age as a prognostic factor in patients with localized melanoma and regional metastases
CM Balch, S Soong, JE Gershenwald… - Annals of surgical …, 2013 - Springer
Background We postulated that the worse prognosis of melanoma with advancing age
reflected more aggressive tumor biology and that in younger patients the prognosis would …
reflected more aggressive tumor biology and that in younger patients the prognosis would …
Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node …
Purpose We have previously reported that older patients with clinical stage I and II primary
cutaneous. Melanoma had lower survival rates compared to younger patients. We …
cutaneous. Melanoma had lower survival rates compared to younger patients. We …
Outcomes of atypical spitz tumors with chromosomal copy number aberrations and conventional melanomas in children
P Gerami, C Cooper, S Bajaj, A Wagner… - The American journal …, 2013 - journals.lww.com
Death due to melanoma in childhood (up to 20 y of age) is a rare event, with an average of
18 cases reported annually in the United States. In this study we evaluated 2 subgroups of …
18 cases reported annually in the United States. In this study we evaluated 2 subgroups of …
Pediatric melanoma: analysis of an international registry
BACKGROUND The management of pediatric melanoma (PM) has largely been
extrapolated from adult data. However, the behavior of PM appears to differ from its adult …
extrapolated from adult data. However, the behavior of PM appears to differ from its adult …
Atypical Spitz tumors in patients younger than 18 years
D Massi, C Tomasini, R Senetta, M Paglierani… - Journal of the American …, 2015 - Elsevier
Background Diagnosis and proper management of atypical Spitz tumors in pediatric age are
still controversial. Objective We sought to investigate the clinicopathological and molecular …
still controversial. Objective We sought to investigate the clinicopathological and molecular …
The unique clinical characteristics of melanoma diagnosed in children
Background Studies have demonstrated a higher rate of nodal metastases in melanoma of
childhood, but there is controversy about the overall prognosis relative to adults. We …
childhood, but there is controversy about the overall prognosis relative to adults. We …
Pediatric and adolescent melanoma: a national cancer data base update
PD Lorimer, RL White, K Walsh, Y Han… - Annals of surgical …, 2016 - Springer
Background Studies suggest that the biology of pediatric and adolescent melanoma differs
from that of adult disease. We report the largest series to date examining the natural history …
from that of adult disease. We report the largest series to date examining the natural history …