Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

Diversifying microRNA sequence and function

SL Ameres, PD Zamore - Nature reviews Molecular cell biology, 2013 - nature.com
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …

LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs

JY Kang, Z Wen, D Pan, Y Zhang, Q Li, A Zhong, X Yu… - Science, 2022 - science.org
Postmeiotic spermatids use a unique strategy to coordinate gene expression with
morphological transformation, in which transcription and translation take place at separate …

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

RY Ebright, S Lee, BS Wittner, KL Niederhoffer… - Science, 2020 - science.org
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …

Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation

A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …

The widespread regulation of microRNA biogenesis, function and decay

J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …

Regulation of mRNA translation and stability by microRNAs

MR Fabian, N Sonenberg… - Annual review of …, 2010 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …

The role of microRNAs in inflammation

K Das, LVM Rao - International Journal of Molecular Sciences, 2022 - mdpi.com
Inflammation is a biological response of the immune system to various insults, such as
pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro …

A translation-activating function of MIWI/piRNA during mouse spermiogenesis

P Dai, X Wang, LT Gou, ZT Li, ZE Wen, ZG Chen… - Cell, 2019 - cell.com
Spermiogenesis is a highly orchestrated developmental process during which chromatin
condensation decouples transcription from translation. Spermiogenic mRNAs are …

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements

LW Barrett, S Fletcher, SD Wilton - Cellular and molecular life sciences, 2012 - Springer
There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …