Overview of microRNA biogenesis, mechanisms of actions, and circulation
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …
Diversifying microRNA sequence and function
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …
now beginning to understand how they are generated, assembled into functional complexes …
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs
JY Kang, Z Wen, D Pan, Y Zhang, Q Li, A Zhong, X Yu… - Science, 2022 - science.org
Postmeiotic spermatids use a unique strategy to coordinate gene expression with
morphological transformation, in which transcription and translation take place at separate …
morphological transformation, in which transcription and translation take place at separate …
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation
A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
The widespread regulation of microRNA biogenesis, function and decay
J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …
that are∼ 21 nucleotides in length and control many developmental and cellular processes …
Regulation of mRNA translation and stability by microRNAs
MR Fabian, N Sonenberg… - Annual review of …, 2010 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …
The role of microRNAs in inflammation
K Das, LVM Rao - International Journal of Molecular Sciences, 2022 - mdpi.com
Inflammation is a biological response of the immune system to various insults, such as
pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro …
pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro …
A translation-activating function of MIWI/piRNA during mouse spermiogenesis
Spermiogenesis is a highly orchestrated developmental process during which chromatin
condensation decouples transcription from translation. Spermiogenic mRNAs are …
condensation decouples transcription from translation. Spermiogenic mRNAs are …
Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements
There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …
the relative amount of non-coding RNA rather than the number of protein-coding genes …