With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

A new scientific frontier opened in 2009 with the start of operations of the world's first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …

INTRODUCTION Photoenzymes are rare biocatalysts driven by absorption of a photon at
each catalytic cycle; they inspire development of artificial photoenzymes with valuable …

The emerging technique of serial X-ray diffraction, in which diffraction data are collected
from samples flowing across a pulsed X-ray source at repetition rates of 100 Hz or higher …

We present a proof-of-concept three-dimensional reconstruction of the giant mimivirus
particle from experimentally measured diffraction patterns from an x-ray free-electron laser …

CrystFEL is a suite of programs for processing data fromserial crystallography'experiments,
which are usually performed using X-ray free-electron lasers (FELs) but also increasingly …

Protein crystallography using synchrotron radiation sources has had a tremendous impact
on biology, having yielded the structures of thousands of proteins and given detailed insight …

The hemoprotein myoglobin is a model system for the study of protein dynamics. We used
time-resolved serial femtosecond crystallography at an x-ray free-electron laser to resolve …

Chromophores absorb light in photosensitive proteins and thereby initiate fundamental
biological processes such as photosynthesis, vision and biofluorescence. An important goal …

Bacteriorhodopsin (bR) is a light-driven proton pump. The primary photochemical event
upon light absorption is isomerization of the retinal chromophore. Here we used time …