The biochemistry of foreign compound metabolism and the roles played by individual
cytochrome P450 (CYP) enzymes in drug metabolism and in the toxification and …

Members of the nuclear-receptor superfamily mediate crucial physiological functions by
regulating the synthesis of their target genes. Nuclear receptors are usually activated by …

ABSTRACT PBREM, the phenobarbital-responsive enhancer module of the cytochrome P-
450 Cyp2b10 gene, contains two potential nuclear receptor binding sites, NR1 and NR2 …

The endogenous CYP2B6 gene becomes phenobarbital (PB) inducible in androstenol-
treated HepG2 cells either transiently or stably transfected with a nuclear receptor CAR …

The cytochrome P450 (CYP) gene products such as CYP3A and CYP2B are essential for
the metabolism of steroid hormones and xenochemicals including prescription drugs …

The fully active dihydroxylated metabolite of vitamin D 3 induces the expression ofCYP3A4
and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human …

The nuclear receptors CAR and PXR activate hepatic genes in response to therapeutic
drugs and xenobiotics, leading to the induction of drug-metabolizing enzymes, such as …

Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …

Phenobarbital (PB) response elements are composed of various nuclear receptor (NR)-
binding sites. A 51-bp distal element PB-responsive enhancer module (PBREM) conserved …

Cytochrome P450 (Cyp) enzymes from the first four families (Cyp1–4) play a major role in
metabolizing xenobiotics, affecting drug pharmacokinetics and chemical-induced toxicity …