Life of RISC: Formation, action, and degradation of RNA-induced silencing complex
Small RNAs regulate a wide variety of biological processes by repressing the expression of
target genes at the transcriptional and post-transcriptional levels. To achieve these …
target genes at the transcriptional and post-transcriptional levels. To achieve these …
Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
T Treiber, N Treiber, G Meister - Nature reviews Molecular cell biology, 2019 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …
[HTML][HTML] Metazoan micrornas
DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development
Z Xiong, K Xu, Z Lin, F Kong, Q Wang, Y Quan… - Nature Cell …, 2022 - nature.com
In mammals, translational control plays critical roles during oocyte-to-embryo transition
(OET) when transcription ceases. However, the underlying regulatory mechanisms remain …
(OET) when transcription ceases. However, the underlying regulatory mechanisms remain …
MicroRNAs: from mechanism to organism
PJ Dexheimer, L Cochella - Frontiers in cell and developmental …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
microRNAs biogenesis, functions and role in tumor angiogenesis
T Annese, R Tamma, M De Giorgis, D Ribatti - Frontiers in oncology, 2020 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification in
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Abstract N 6-methyladenosine (m 6 A) is the most abundant internal modification in
eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and …
eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and …
Codon optimality, bias and usage in translation and mRNA decay
G Hanson, J Coller - Nature reviews Molecular cell biology, 2018 - nature.com
The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …
MicroRNA in control of gene expression: an overview of nuclear functions
C Catalanotto, C Cogoni, G Zardo - International journal of molecular …, 2016 - mdpi.com
The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a
sequence specific manner has had a massive impact on biology. Recent improvements in …
sequence specific manner has had a massive impact on biology. Recent improvements in …