Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals.
The disease was initially described in the 16th century and was the first animal pathogen …

The major medical importance of flaviviruses has fostered studies into their molecular
biology in research laboratories around the world. Although the molecular biology of …

In positive-stranded viruses, the genomic RNA serves as a template for both translation and
RNA replication. Using poliovirus as a model, we examined the interaction between these …

Current understanding of the molecular basis of pathogenesis of foot-and-mouth disease
(FMD) has been achieved through over 100 years of study into the biology of the etiologic …

Poliovirus RNA replicative complexes are associated with cytoplasmic membranous
structures that accumulate during viral infection. These membranes were immunoisolated by …

Publisher Summary It is clear from the experimental data that there are some similarities in
RNA replication for all eukaryotic positive-stranded RNA viruses—that is, the mechanism of …

Picornaviruses cause several diseases, not only in humans but also in various animal hosts.
For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina …

A cloverleaf structure at the 5′ terminus of poliovirus RNA binds viral and cellular proteins.
To examine the role of the cloverleaf in poliovirus replication, we determined how cloverleaf …

The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a
complementary minus strand. This process is initiated by the covalent attachment of UMP to …

The 65 serotypes of human enteroviruses are classified into four species, Human
enterovirus (HEV) A to D, based largely on phylogenetic relationships in multiple genome …