Urogenital schistosomiasis, infection with Schistosoma haematobium, is linked to increased
risk for the development of bladder cancer, but the importance of various mechanisms …

Dysregulation of fibroblast growth factor receptors (FGFRs) has been implicated in several
human malignancies, including urothelial carcinoma. In urothelial carcinoma, the oncogenic …

Relationships between genetic alterations, such as co-occurrence or mutual exclusivity, are
often observed in cancer, where their understanding may provide new insights into etiology …

Activating mutations of fibroblast growth factor receptor-3 (FGFR3) have been described in
approximately 75% of low-grade papillary bladder tumors. In muscle-invasive disease …

Background Infiltrating UC represents the second most common genitourinary malignancy.
Advanced UC has a poor prognosis and new treatments are needed. Molecular profiling of …

Simple Summary Bladder cancer (BC) is a common cancer that causes high morbidity and
mortality among affected patients. As a carcinogen-driven cancer, molecular oncology of BC …

Background Fibroblast growth factor receptor 3 (FGFR3) is an actionable target in bladder
cancer. Preclinical studies show that anti-FGFR3 treatment slows down tumor growth …

Background Despite years of slow progress, muscle invasive bladder cancer (MIBC) is
finally entering the era of molecularly guided targeted therapy. However, tumor …

Bladder cancer (BC) is one of the most common malignancies. Two previous studies
identified collagen type V alpha 2 (COL5A2) as a potential biomarker in BC, both are simple …

Aims The dual pathway model of urothelial carcinogenesis does not fully explain grade and
stage progression in patients with initial low‐grade, non‐muscle invasive urothelial …