The goal this review is to clarify the effects of the fat mass and obesity-associated protein
(FTO) in lipid metabolism regulation and related underlying mechanisms through the FTO …

Obesity rates are increasing almost everywhere in the world, although the pace and timing
for this increase differ when populations from developed and developing countries are …

Metabolic inflammation is closely linked to obesity, and is implicated in the pathogenesis of
metabolic diseases. FTO harbors the strongest genetic association with polygenic obesity …

The de novo differentiation of hyperplastic adipocytes from adipocyte progenitor cells
(APCs) is accompanied by a reduction in adipose tissue fibrosis and inflammation and …

Obesity is mainly due to excessive food intake. IRX3 and IRX5 have been suggested as
determinants of obesity in connection with the intronic variants of FTO, but how these genes …

Objective Consuming sweet foods, even when sated, can lead to unwanted weight gain.
Contextual factors, such as longer time fasting, subjective hunger, and body mass index …

Genome-wide association studies (GWASs) have identified SNPs of the fat mass and
obesity (FTO) gene as the most important risk alleles for obesity. However, how the …

Genome‐wide association studies have revealed a plethora of genetic variants that
correlate with polygenic conditions. However, causal molecular mechanisms have proven …

Background Lifestyle intervention may have a critical effect on the association between
genetics and obesity. This study aimed to investigate changes in FTO and IRX3 gene …

Metabolic-associated fatty liver disease (MAFLD) affects approximately a quarter of the
global population. Identification of the key genes and pathways involved in hepatic lipid …