Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory

EJ Jaehne, JN Kent, EJ Antolasic, BJ Wright… - Translational …, 2022 - nature.com
The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is
associated with reduced activity-dependent BDNF release and increased risk for anxiety …

Cell type–specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis

R Chen, Y Liu, MN Djekidel, W Chen… - Science …, 2022 - science.org
Schizophrenia (SCZ) is a chronic, serious mental disorder. Although more than 200 SCZ-
associated genes have been identified, the underlying molecular and cellular mechanisms …

[HTML][HTML] microRNA-146a modulates behavioural activity, neuroinflammation, and oxidative stress in adult mice

W Zhao, JG Spiers, N Vassileff, A Khadka… - Molecular and Cellular …, 2023 - Elsevier
Small non-coding miRNA act as key regulators of several physiological processes due to
their ability to interact with numerous target mRNA within a network. Whilst several miRNA …

The Role of PLAG1 in Mouse Brain Development and Neurogenesis

JG Gasperoni, SC Tran, SVH Grommen… - Molecular …, 2024 - Springer
The pleomorphic adenoma gene 1 (Plag1) is a transcription factor involved in the regulation
of growth and cellular proliferation. Here, we report the spatial distribution and functional …

[HTML][HTML] RNA-seq identifies differentially expressed genes involved in csal1 overexpression in granulosa cells of prehierarchical follicles in Chinese Dagu hens

H Zhu, Y Ding, J Zhu, L Zhao, Y Su, S Zhao - Poultry Science, 2023 - Elsevier
The transcription factor csal1 is an important molecule that plays a critical regulatory function
in ovarian follicle development, as confirmed by our previous data. However, the candidate …

How to measure exploration: A combined estimation method.

R Beukeboom, D Benhaïm - Behavioural Processes, 2024 - Elsevier
The personality axis 'exploration-avoidance'is often measured using an open field test (OFT)
from which measurements such as mobility level (eg distance travelled) and space use (eg …

Administering a Behavioral Test Battery in Rodents

EJ Jaehne, M Corrone, M van den Buuse - Neurobiology: Methods and …, 2023 - Springer
Although animal models cannot broadly represent uniquely human psychiatric or
psychological syndromes such as anxiety, depression, or schizophrenia, behavioral testing …