The human microbiome and its metabolic output play an important role in shaping human
health and disease. The host-microbe crosstalk is often characterised using metabolomics …

The growing demand for sustainable solutions in agriculture, which are critical for crop
productivity and food quality in the face of climate change and the need to reduce …

The identification of molecular structure is essential for understanding chemical diversity and
for developing drug leads from small molecules. Nevertheless, the structure elucidation of …

The spectral database-based mass spectrometry (MS) matching strategy is versatile for
structural annotating in ingredient fluctuation profiling mediated by external interferences …

A continued rise of antibiotic resistance and shortages of effective antibiotics necessitate the
discovery and development of new antibiotics with novel modes of action (MoAs) against …

Natural scaffolds remain an important basis for drug development. Therefore, approaches to
natural bioactive compound discovery attract significant attention. In this account, we …

Untargeted metabolomics promises comprehensive characterization of small molecules in
biological samples. However, the field is hampered by low annotation rates and abstract …

In deep-sea cold seeps, microbial communities thrive on the geological seepage of
hydrocarbons and inorganic compounds, differing from photosynthetically driven …

This research introduces a systems theory-driven framework to integration artificial
intelligence (AI) into traditional Chinese medicine (TCM) research, enhancing the …

Co-cultivation is an effective method of inducing the production of specialized metabolites
(SMs) in microbial strains. By mimicking the ecological interactions that take place in natural …