The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

In this review we examine the effects of the allosteric activator, acetyl CoA on both the
structure and catalytic activities of pyruvate carboxylase. We describe how the binding of …

Histone deacetylase (HDAC) inhibitors, including various benzamides and hydroxamates,
are currently in clinical development for a broad range of human diseases, including cancer …

Revised Manuscript Received October 8, 1992 abstract: A peptide (PCB1) corresponding to
the proregion of the rat cysteine protease cathepsin B was synthesized and its ability to …

Amastatin [(2S, 3P)-3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L-aspartic acid]
and bestatin [(2S, 3fl)-3-amino-2-hydroxy-4-phenylbutanoyl-L-leucine] are slow-binding …

The rates of most physical, chemical and biological processes vary with temperature and
numerous instances have been reported in which Arrhenius plots of the experimental data …

In the presence of a reporter substrate, the progressive inactivation of an enzyme was easily
studied by directly transmitting absorbance readings to a microcomputer. Pseudo-first order …

Long-term caloric restriction (CR) has been shown to extend maximum life span in
laboratory rodents. We investigated the activities of gluconeogenic and transaminase …

Compounds containing a 1-cyanopyrrolidinyl ring were identified as potent and reversible
inhibitors of cathepsins K and L. The original lead compound 1 inhibits cathepsins K and L …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play important
roles in physiological and pathological conditions. Both gelatinases (MMP-2 and-9) and …