Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective
H Pei, W Guo, Y Peng, H Xiong… - Medicinal Research …, 2022 - Wiley Online Library
The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …
Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA
In this review we examine the effects of the allosteric activator, acetyl CoA on both the
structure and catalytic activities of pyruvate carboxylase. We describe how the binding of …
structure and catalytic activities of pyruvate carboxylase. We describe how the binding of …
[HTML][HTML] Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases
CJ Chou, D Herman, JM Gottesfeld - Journal of Biological Chemistry, 2008 - ASBMB
Histone deacetylase (HDAC) inhibitors, including various benzamides and hydroxamates,
are currently in clinical development for a broad range of human diseases, including cancer …
are currently in clinical development for a broad range of human diseases, including cancer …
Potent slow-binding inhibition of cathepsin B by its propeptide
T Fox, E De Miguel, JS Mort, AC Storer - Biochemistry, 1992 - ACS Publications
Revised Manuscript Received October 8, 1992 abstract: A peptide (PCB1) corresponding to
the proregion of the rat cysteine protease cathepsin B was synthesized and its ability to …
the proregion of the rat cysteine protease cathepsin B was synthesized and its ability to …
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes
DH Rich, BJ Moon, S Harbeson - Journal of medicinal chemistry, 1984 - ACS Publications
Amastatin [(2S, 3P)-3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L-aspartic acid]
and bestatin [(2S, 3fl)-3-amino-2-hydroxy-4-phenylbutanoyl-L-leucine] are slow-binding …
and bestatin [(2S, 3fl)-3-amino-2-hydroxy-4-phenylbutanoyl-L-leucine] are slow-binding …
Regression analysis of nonlinear Arrhenius plots: an empirical model and a computer program
RG Duggleby - Computers in biology and medicine, 1984 - Elsevier
The rates of most physical, chemical and biological processes vary with temperature and
numerous instances have been reported in which Arrhenius plots of the experimental data …
numerous instances have been reported in which Arrhenius plots of the experimental data …
Automated analysis of enzyme inactivation phenomena: application to β-lactamases and DD-peptidases
F De Meester, B Joris, G Reckinger… - Biochemical …, 1987 - Elsevier
In the presence of a reporter substrate, the progressive inactivation of an enzyme was easily
studied by directly transmitting absorbance readings to a microcomputer. Pseudo-first order …
studied by directly transmitting absorbance readings to a microcomputer. Pseudo-first order …
Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver
K Hagopian, JJ Ramsey, R Weindruch - Experimental gerontology, 2003 - Elsevier
Long-term caloric restriction (CR) has been shown to extend maximum life span in
laboratory rodents. We investigated the activities of gluconeogenic and transaminase …
laboratory rodents. We investigated the activities of gluconeogenic and transaminase …
Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L
JP Falgueyret, RM Oballa, O Okamoto… - Journal of medicinal …, 2001 - ACS Publications
Compounds containing a 1-cyanopyrrolidinyl ring were identified as potent and reversible
inhibitors of cathepsins K and L. The original lead compound 1 inhibits cathepsins K and L …
inhibitors of cathepsins K and L. The original lead compound 1 inhibits cathepsins K and L …
[HTML][HTML] Potent mechanism-based inhibitors for matrix metalloproteinases
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play important
roles in physiological and pathological conditions. Both gelatinases (MMP-2 and-9) and …
roles in physiological and pathological conditions. Both gelatinases (MMP-2 and-9) and …