Highlights•Parathyroid hormone has dual anabolic and catabolic actions on the
skeleton.•The OPG–RANKL–RANK pathway is the main mediator of the catabolic actions of …

The balance between bone formation and bone resorption controls postnatal bone
homeostasis. Research over the last decade has provided a vast amount of evidence that …

Developing peptide-based tools to fine-tune growth signaling pathways, in particular
molecules with exquisite selectivity and high affinities, opens up opportunities for cellular …

Abstract Introduction Sclerostin is a Wnt inhibitor produced by osteocytes that regulates
bone formation. Because bone tissue contributes to the development of osteoarthritis (OA) …

Sclerostin, encoded by the Sost gene, is an important negative regulator of bone formation
that has been proposed to have a key role in regulating the response to mechanical loading …

We identified previously in vitro LRP4 (low-density lipoprotein receptor-related protein 4) as
a facilitator of the WNT (Wingless-type) antagonist sclerostin and found mutations disrupting …

WNT1 mutations in humans are associated with a new form of osteogenesis imperfecta and
with early-onset osteoporosis, suggesting a key role of WNT1 in bone mass regulation …

Physical mechanical stimulation can maintain and even increase bone mass. Here, we
report an important role of osteocytic integrin α5 in regulating the anabolic response of bone …

Fat and bone have a complicated relationship. Although obesity has been associated with
low fracture risk, there is increasing evidence that some of the factors that are released by …

It is estimated that over 200 million adults worldwide have osteoporosis, a disease that has
increasing socioeconomic impact reflected by unsustainable costs associated with disability …