DNA methylation profiles in cancer diagnosis and therapeutics

Y Pan, G Liu, F Zhou, B Su, Y Li - Clinical and experimental medicine, 2018 - Springer
Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

DNA methylation profiling in the clinic: applications and challenges

H Heyn, M Esteller - Nature Reviews Genetics, 2012 - nature.com
Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

DNA methylation biomarkers: cancer and beyond

T Mikeska, JM Craig - Genes, 2014 - mdpi.com
Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Point-of-care cancer diagnostic devices: From academic research to clinical translation

L Syedmoradi, ML Norton, K Omidfar - Talanta, 2021 - Elsevier
Early and timely diagnosis of cancer plays a decisive role in appropriate treatment and
improves clinical outcomes, improving public health. Significant advances in biosensor …

Cancer epigenetic biomarkers in liquid biopsy for high incidence malignancies

C Palanca-Ballester, A Rodriguez-Casanova, S Torres… - Cancers, 2021 - mdpi.com
Simple Summary Apart from genetic changes, cancer is characterized by epigenetic
alterations, which indicate modifications in the DNA (such as DNA methylation) and histones …

Glycans as biomarkers in prostate cancer

E Scott, J Munkley - International journal of molecular sciences, 2019 - mdpi.com
Prostate cancer is the most commonly diagnosed malignancy in men, claiming over 350,000
lives worldwide annually. Current diagnosis relies on prostate-specific antigen (PSA) testing …

[HTML][HTML] The importance of DNA methylation in prostate cancer development

CE Massie, IG Mills, AG Lynch - The Journal of steroid biochemistry and …, 2017 - Elsevier
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

Epigenetic modifications in prostate cancer

M Sugiura, H Sato, M Kanesaka… - … Journal of Urology, 2021 - Wiley Online Library
Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …

Cell-free DNA as a diagnostic marker for cancer: current insights

S Salvi, G Gurioli, U De Giorgi, V Conteduca… - Oncotargets and …, 2016 - Taylor & Francis
The increasing knowledge of the molecular pathogenesis of cancer and the rapid
development of new molecular techniques are promoting the study of early molecular …