Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

Articular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical
distribution of loads across the joints. The majority of its structure and function is controlled …

Background Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely
investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of …

Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that is the most
common joint disease worldwide. Mesenchymal stem cells (MSCs) have been the most …

Background Mesenchymal stromal cells are a promising option to treat knee osteoarthritis.
Their safety and usefulness must be confirmed and the optimal dose established. We tested …

Background Osteoarthritis (OA) is a common and debilitating chronic degenerative disease
of the joints. Currently, cell-based therapy is being explored to address the repair of …

Background Osteoarthritis is the most prevalent joint disease and a frequent cause of joint
pain, functional loss, and disability. Osteoarthritis often becomes chronic, and conventional …

Stem cells hold great promise for the treatment of multiple human diseases and disorders.
Tracking and monitoring of stem cells in vivo after transplantation can supply important …

Mesenchymal stem/stromal cells (MSCs) are promising cell sources for regenerative
therapies due to their multipotency and ready availability, but their application can be …

Dysfunction of mRNA or RNA-binding proteins (RBPs) causes cellular aging and age-
related degenerative diseases; however, information regarding the mechanism through …