Pancreatic ductal adenocarcinoma (PDAC) is a highly life-threatening tumour with a low
early-detection rate, rapid progression and a tendency to develop resistance to …

Epigenetic alterations, such as changes in DNA methylation, histones/chromatin structure,
nucleosome positioning, and expression of non-coding RNAs, are recognized among key …

Pancreatic cancer (PACA), which is characterized by an immunosuppressive nature,
remains one of the deadliest malignancies worldwide. Aberrant DNA methylation (DNAm) …

Background Examining immunity-related DNA methylation alterations in blood could help
elucidate the role of the immune response in lung cancer etiology and aid in discovering …

The role of DNA methylation and its interplay with gene expression in the susceptibility to
pancreatic cancer (PanC) remains largely unexplored. To fill in this gap, we conducted an …

Background. Increasing evidence exists of a link between DNA methylation and tumor
immunotherapy. However, the impact of DNA methylation on the characteristics of the lung …

Background: Evidence is accumulating that immune cells play a prominent role in pancreatic
cancer etiology but prospective investigations are missing. Methods: We conducted a nested …

Prior cohort studies assessing cancer risk based on immune cell subtype profiles have
predominantly focused on White populations. This limitation obscures vital insights into how …

DNA methylation is an epigenetic phenomenon that can alter and control gene expression.
Because methylation plays a key role in cell differentiation, methylation markers have been …

Integrative genomic data analysis is a powerful tool to study the complex biological
processes behind a disease. Statistical methods can model the interrelationships of the …