Approximately one-quarter of strokes occur in individuals with prior stroke. Despite the
advancement in secondary stroke prevention, the long-term risk of recurrent stroke has …

Importance Although increasing evidence suggests that trimethylamine N-oxide (TMAO) is
associated with atherosclerosis, little is known about whether TMAO and its related …

Background Dietary choices can affect human health through alterations in gut microbial
metabolism, and gut microbial metabolites could serve as biomarkers for disease risk …

BACKGROUND: The American Heart Association's Life's Simple 7 (LS7) is a health metric
that captures important factors associated with cardiovascular and cerebrovascular health …

We examined associations between lipidomic profiles and incident ischemic stroke in the
REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Plasma lipids …

Background: To estimate the associations of stroke risk with plasma metabolites, metabolic
risk score (MRS), the combinations of MRS with hypertension or lifestyle, and lifestyle …

Coronary heart disease remains a major global health challenge, with a clear need for
enhanced early risk assessment. This study aimed to elucidate metabolic signatures across …

Metabolomic data often present challenges due to high dimensionality, collinearity, and
variability in metabolite concentrations. Machine learning (ML) application in metabolomic …

This study aimed to analyze the effects of systemic arterial hypertension (SAH) in a model of
permanent ischemic stroke (focal ischemia due to thermocoagulation of pial vessels) on …

Aim: To identify novel metabolic biomarkers for patients with acute ischemic stroke (AIS).
Methods: The metabolites in the sera of 63 patients with AIS aged 45∼ 77 years and 60 …