Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …

Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME)
that, among its many functions, enables the evasion of T cell-mediated immune responses …

Photothermal immunotherapy has shown great promise in the treatment of tumor metastasis.
However, the thermal resistance of tumor cells substantially compromises the treatment …

Uncontrolled regeneration leads to neoplastic transformation,–. The intestinal epithelium
requires precise regulation during continuous homeostatic and damage-induced tissue …

Tumor-infiltrating B cells play a significant role in tumor development, progression, and
prognosis, yet a comprehensive classification system is lacking. To address this gap, we …

Introduction Over the past four years, the COVID-19 pandemic has posed serious global
health challenges. The severe form of disease and death resulted from the failure of immune …

Cancer immunotherapy has emerged as a promising approach in cancer treatment and is
considered a major advancement after surgical interventions, radiotherapy, chemotherapy …

Pancreatic cancer remains one of the most aggressive solid tumors. As a systemic disease,
despite the improvement of multi-modality treatment strategies, the prognosis of pancreatic …

Non-alcoholic fatty liver disease (NAFLD) exhibits increased lipid enrichment in
hepatocytes. The spectrum of this disease includes stages such as nonalcoholic simple fatty …

Simple Summary Osteosarcoma (OS) is the most common bone tumor in the pediatric
population. Currently, no effective molecularly targeted therapies are available for OS. The …