Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …

Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is
linked with high morbidity and mortality. Diabetic cardiomyopathy (DCM) often manifests as …

Unveiling the secrets of genome's flexibility does not only foster new research in the field,
but also gives rise to the exploration and development of novel epigenetic-based therapies …

Histones display a wide variety of post-translational modifications, including acetylation,
methylation, and phosphorylation. These epigenetic modifications can influence chromatin …

CRISPR/Cas9, a highly versatile genome-editing tool, has garnered significant attention in
recent years. Despite the unique characteristics of oocytes and early embryos compared to …

Chronic heart failure is a terminal point of a vast majority of cardiac or extracardiac causes
affecting around 1–2% of the global population and more than 10% of the people above the …

Epigenetic regulation of gene expression, including DNA methylation and histone
modifications, provides finely tuned responses for cells that undergo cellular environment …

Diabetic cardiomyopathy (DCM) is characterized by diastolic relaxation abnormalities in its
initial stages and by clinical heart failure (HF) without dyslipidemia, hypertension, and …