Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney
disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD …

One of the most frequent complications in patients with diabetes mellitus is diabetic
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …

Background Systemic immune-inflammation index (SII) is a novel inflammatory marker, and
inflammation has been reported to be related with renal damage. We aimed to investigate …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Many lines of evidence, ranging from in vitro experiments and pathological examinations to
epidemiological studies, show that inflammation is a cardinal pathogenetic mechanism in …

Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy,
which is the largest single cause of end‐stage renal disease and a medical catastrophe of …

Cytokines act as pleiotropic polypeptides regulating inflammatory and immune responses
through actions on cells. They provide important signals in the pathophysiology of a range of …

Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …

Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD).
Over the past two decades, there has been significant clarification of the various pathways …

Tumor necrosis factor (TNF), initially reported to induce tumor cell apoptosis and cachexia, is
now considered a central mediator of a broad range of biological activities from cell …