Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

There is an art and science to performing mouse anesthesia, which is a significant
component to animal research. Frequently, anesthesia is one vital step of many over the …

Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is
reliable, that animals provide sufficiently good models of human biology and diseases to …

Facial expression is widely used as a measure of pain in infants; whether nonhuman
animals display such pain expressions has never been systematically assessed. We …

Pain is a subjective and multidimensional experience that is often inadequately managed in
clinical practice. Effective control of postoperative pain is important after anesthesia and …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Acute postoperative pain is followed by persistent pain in 10–50% of individuals after
common operations, such as groin hernia repair, breast and thoracic surgery, leg …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable
nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 …

The premier single-volume reference in the field of anesthesia, Clinical Anesthesia is now in
its Sixth Edition, with thoroughly updated coverage, a new full-color design, and a revamped …