The interactions of various low-molecular weight substances with DNA are naturally relevant
mechanisms in the cellular cycle and so also used in medicinal treatment. Depending on the …

Severe combined immunodeficient (SCID) mice transplanted with human bone marrow were
treated with human mast cell growth factor, a fusion of interleukin-3 and granulocyte …

Expression of Thy-1 on hematopoietic cells from human fetal liver (FL), cord blood (CB), and
bone marrow (BM) was studied with a novel anti-Thy-1 antibody, 5E10. Specificity of 5E10 …

The successful engraftment of human hematopoietic cells into immune-deficient mice offers
a novel approach to characterize the developmental program of human hematopoiesis …

Using a fragment of the murine flt3 ligand as a probe, we have succeeded in cloning a
human flt3 ligand from a human T-cell lambda gt10 cDNA library. The human and murine …

TO produce a vaccine against cancer, antigens must be found that are preferentially
expressed by tumour cells and can induce an immune response against the tumour. The …

Abstract Interleukin-12 (IL-12) is unique amongst cytokines in being a disulfide-linked
heterodimer of two separately encoded subunits (p35 and p40). We expressed single chain …

To directly study the biological properties of purified hematopoietic colony-forming cell
precursors, cells with a CD34+ CD45RAlo CD71lo phenotype were purified from human …

ligand for the tyrosine kinase receptor flt3/flk-2, referred to here as flt3 ligand (flt3L), was
recently cloned. The effect of flt3L on purified human CD34+ progenitor cells was examined …

To test the effect of the physical proximity of two enzymes catalyzing sequential reactions, a
bifunctional fusion enzyme, TPSP, was constructed by fusing the Escherichia coli genes for …