Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions
H Ji, C Hu, X Yang, Y Liu, G Ji, S Ge, X Wang… - … and Targeted Therapy, 2023 - nature.com
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …
modulation, and secondary dissemination to distant sites through a series of mechanisms …
Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets
Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
Lysophosphatidic acid receptor antagonists and cancer: the current trends, clinical implications, and trials
Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …
Roles of reactive oxygen species in biological behaviors of prostate cancer
C Han, Z Wang, Y Xu, S Chen, Y Han… - BioMed research …, 2020 - Wiley Online Library
Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and
mortality rate around the world and seriously threatens public health. As an inevitable by …
mortality rate around the world and seriously threatens public health. As an inevitable by …
DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism
DNA‐PKcs is a key regulator of DNA double‐strand break repair. Apart from its canonical
role in the DNA damage response, DNA‐PKcs is involved in the cellular response to …
role in the DNA damage response, DNA‐PKcs is involved in the cellular response to …
Lysophosphatidic acid: promoter of cancer progression and of tumor microenvironment development. a promising target for anticancer therapies?
S Aiello, F Casiraghi - Cells, 2021 - mdpi.com
Increased expression of the enzyme autotaxin (ATX) and the consequently increased levels
of its product, lysophosphatidic acid (LPA), have been reported in several primary tumors …
of its product, lysophosphatidic acid (LPA), have been reported in several primary tumors …
Targeting lysophosphatidic acid in cancer: the issues in moving from bench to bedside
Y Xu - Cancers, 2019 - mdpi.com
Since the clear demonstration of lysophosphatidic acid (LPA)'s pathological roles in cancer
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …
The “Janus Face” of platelets in cancer
MV Catani, I Savini, V Tullio, V Gasperi - International journal of molecular …, 2020 - mdpi.com
Besides their vital role in hemostasis and thrombosis, platelets are also recognized to be
involved in cancer, where they play an unexpected central role: They actively influence …
involved in cancer, where they play an unexpected central role: They actively influence …
Calreticulin as a marker and therapeutic target for cancer
M Zhang, J Xiao, J Liu, X Bai, X Zeng, Z Zhang… - Clinical and Experimental …, 2023 - Springer
Calreticulin (CRT) is a multifunctional protein found within the endoplasmic reticulum (ER).
In addition, CRT participates in the formation and development of tumors and promotes the …
In addition, CRT participates in the formation and development of tumors and promotes the …