Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …

Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and
mortality rate around the world and seriously threatens public health. As an inevitable by …

DNA‐PKcs is a key regulator of DNA double‐strand break repair. Apart from its canonical
role in the DNA damage response, DNA‐PKcs is involved in the cellular response to …

Increased expression of the enzyme autotaxin (ATX) and the consequently increased levels
of its product, lysophosphatidic acid (LPA), have been reported in several primary tumors …

Since the clear demonstration of lysophosphatidic acid (LPA)'s pathological roles in cancer
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …

Besides their vital role in hemostasis and thrombosis, platelets are also recognized to be
involved in cancer, where they play an unexpected central role: They actively influence …

Calreticulin (CRT) is a multifunctional protein found within the endoplasmic reticulum (ER).
In addition, CRT participates in the formation and development of tumors and promotes the …