Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

Neurodegenerative disorders (ND) are a group of conditions that affect the neurons in the
brain and spinal cord, leading to their degeneration and eventually causing the loss of …

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

It is well established that ryanodine receptors (RyanRs) are overactive in Alzheimer's
disease (AD), and it has been suggested that inhibition of RyanR is potentially beneficial for …

Two of the most common neurodegenerative disorders–Alzheimer's and Parkinson's
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …

The disturbance in mitochondrial functions and homeostasis are the major features of
neuron degenerative conditions, like Parkinson's disease, Amyotrophic Lateral Sclerosis …

The accumulation of the small 42‐residue long peptide amyloid‐β (Aβ) has been proposed
as a major trigger for the development of Alzheimer's disease (AD). Within the brain, the …

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease,
which has a high heritability of up to 79%. Exploring the genetic basis is essential for …

Proteolysis catalyzed by the major lysosomal aspartyl protease cathepsin-D (CTSD)
appears to be of pivotal importance for proteostasis within the central nervous system and in …

More than seven decades have passed since the discovery of a proteolytic activity within
crude tissue extracts that would become known as insulin-degrading enzyme (IDE) …