Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Quinones represent a class of toxicological intermediates which can create a variety of
hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis …

Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …

Invited Review Page 1 Invited Review Dihydrodiol Dehydrogenases and Polycyclic
Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones …

Aldo-keto reductases (AKRs) are soluble NAD (P)(H) oxidoreductases that primarily reduce
aldehydes and ketones to primary and secondary alcohols, respectively. The ten known …

Polycyclic aromatic hydrocarbons are ubiquitous contaminants in the environment. Benzo [a]
pyrene (BaP), a prototypical member of this class of chemicals, has been extensively studied …

The ability to conduct validated analyses of biomarkers is critically important in order to
establish the sensitivity and selectivity of the biomarker in identifying a particular disease …

There is a clear association between the excessive exposure to estrogens and the
development of cancer in hormone-sensitive tissues (breast, endometrium). It has become …

Dihydrodiol dehydrogenase (DD; EC 1.3. 1.20) catalyzes the oxidation of polycyclic aromatic
hydrocarbon (PAH) trans-dihydrodiols (proximate carcinogens) to catechols which rapidly …

Polycyclic aromatic hydrocarbons (PAH) are environmental pollutants and suspected human
lung carcinogens. In patients with non-small cell lung carcinoma, differential display shows …