Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …

Although reactive oxygen species (ROS) are essential for cellular processes, excessive
ROS could be a major cause of various inflammatory diseases because of the oxidation of …

Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-
reperfusion injury in the heart and several degenerative diseases, including muscular …

Reactive oxygen species (ROS) are generated in skeletal muscle both during the rest and
contractile activity. Myogenic cells are equipped with antioxidant enzymes, like superoxide …

Background Improvements in poultry production within the past 50 years have led to
increased muscle yield and growth rate, which may be contributing to an increased rate and …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Background Maintaining skeletal muscle mitochondrial content and function is important for
sustained health throughout the lifespan. Exercise stimulates important key stress signals …

Reactive oxygen species (ROS) have emerged as regulators of key processes supporting
neuronal growth, function, and plasticity across lifespan. At normal physiological levels, ROS …

Muscle loss due to fibrotic or adipogenic replacement of myofibers is common in muscle
diseases and muscle-resident fibro/adipogenic precursors (FAPs) are implicated in this …