The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids

P Amoa Onguéné, F Ntie-Kang, LL Lifongo, JC Ndom… - Malaria journal, 2013 - Springer
Traditional medicine caters for about 80% of the health care needs of many rural
populations around the world, especially in developing countries. In addition, plant-derived …

Therapeutic potentials of antiviral plants used in traditional african medicine with COVID-19 in focus: a Nigerian perspective

AF Attah, AA Fagbemi, O Olubiyi… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic is caused by an infectious novel strain
of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells

K Bonjean, MC De Pauw-Gillet, MP Defresne… - Biochemistry, 1998 - ACS Publications
Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of
Cryptolepis sanguinolenta. It is characterized by a multiplicity of host-mediated biological …

Computer-assisted structure verification and elucidation tools in NMR-based structure elucidation

ME Elyashberg, AJ Williams, GE Martin - Progress in Nuclear Magnetic …, 2008 - Elsevier
Laboratories around the world are challenged by the task of either verifying chemical
structures or elucidating the chemical structures of unknowns; each structure verified or …

Ethnobotanical-Directed Discovery of the Antihyperglycemic Properties of Cryptolepine: Its Isolation from Cryptolepis sanguinolenta, Synthesis, and in Vitro and in …

DE Bierer, DM Fort, CD Mendez, J Luo… - Journal of medicinal …, 1998 - ACS Publications
Using an ethnobotanical approach in combination with in vivo-guided fractionation as a
means for lead discovery, cryptolepine was isolated as an antihyperglycemic component of …

Two new indoloquinoline alkaloids from cryptolepis sanguinolenta: Cryptosanguinolentine and cryptotackieine

MHM Sharaf, PL Schiff Jr, AN Tackie… - Journal of …, 1996 - Wiley Online Library
The roots of the indigenous West African shrub Cryptolepis sanguinolenta have proved to be
a rich source of indoloquinoline alkaloids. To date, all of the alkaloids isolated have been …

A Bioactivity Versus Ethnobotanical Survey of Medicinal Plants from Nigeria, West Africa

LL Lifongo, CV Simoben, F Ntie-Kang… - Natural products and …, 2014 - Springer
Traditional medicinal practices play a key role in health care systems in countries with
developing economies. The aim of this survey was to validate the use of traditional medicine …

Cryptospirolepine, a unique spiro-nonacyclic alkaloid isolated from Cryptolepis sanguinolenta

AN Tackie, GL Boye, MHM Sharaf… - Journal of Natural …, 1993 - ACS Publications
From the alkaloidal fractions of the West African plant Cryptolepis san-guinolenta
(Asclepiadaceae), two alkaloids were purified: one was identified as the known …

Isolation, biological activities and synthesis of indoloquinoline alkaloids: cryptolepine, isocryptolepine and neocryptolepine

P T. Parvatkar, P S. Parameswaran… - Current Organic …, 2011 - benthamdirect.com
The tetracyclic heteroaromatic compounds cryptolepine, isocryptolepine and
neocryptolepine are all naturally occurring indoloquinoline alkaloids isolated from the shrub …

New alkaloids from Cryptolepis sanguinolenta

A Paulo, ET Gomes, PJ Houghton - Journal of Natural Products, 1995 - ACS Publications
An extract of Cryptolepis sanguinolenta yielded five alkaloids. Twoof these were the known
compounds cryptolepine [11 and quindoline [2]. Three of the compounds have not been …