Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans. We
examined the role of the interleukin (IL)-23–IL-17 and IL-12–T helper cell (Th) 1 pathways in …

Understanding the immunopathogenesis of autoimmune and inflammatory diseases is a
prerequisite for specific and effective therapeutical intervention. This review focuses on …

PURPOSE: To quantify S-antigen-specific (S-Ag) T cells in the retina after adoptive transfer,
and to evaluate their role in the initiation and progress of destructive ocular inflammation in …

The aim of this study was to investigate the effect of anti-mouse IL-6 receptor monoclonal
antibody (MR16-1) treatment on CD4 T cell differentiation and compared it to the effect of …

purpose. To investigate the antigenic specificity of the immune neuroprotective mechanism
that can protect retinal ganglion cells (RGCs) against death caused by high intraocular …

In contrast to rats, mouse models are nowadays generally used for the investigation of
immune responses and immune-mediated diseases, there are many different strains and …

Although the role of ocular antigens in the pathogenesis of inflammatory diseases of the eye
has been investigated since early in this century, it was not until 1965 that Wacker and …

Renin angiotensin system (RAS) is a key hormonal system which regulates the
cardiovascular function and is implicated in several autoimmune diseases. With the …

Interest in the identities, properties, functions, and origins of local APC in CNS tissues is
growing. We recently reported that dendritic cells (DC) distinct from microglia were present …

PURPOSE: Mice of the H-2b, H-2k, and H-2r haplotypes develop experimental autoimmune
uveoretinitis (EAU) after immunization with interphotoreceptor retinoid-binding protein …