Polycaprolactone and its derivatives for drug delivery

R Pawar, A Pathan, S Nagaraj… - Polymers for …, 2023 - Wiley Online Library
Polycaprolactone (PCL) is polymer of 21st centuries. PCL is a biodegradable and
biocompatible polymer used for various healthcare applications. This review explores the …

Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects

N Pathak, AS Negi - European Journal of Medicinal Chemistry, 2024 - Elsevier
Plants are rich in steroidal and triterpenoid saponins. Diosgenin is an important sapogenin
obtained from various steroidal saponins and specially from dioscin. It possesses diverse …

Synthesis and characterization of diosgenin encapsulated poly-ε-caprolactone-pluronic nanoparticles and its effect on brain cancer cells

B Rabha, KK Bharadwaj, D Baishya, T Sarkar… - Polymers, 2021 - mdpi.com
Diosgenin encapsulated PCL-Pluronic nanoparticles (PCL-F68-D-NPs) were developed
using the nanoprecipitation method to improve performance in brain cancer (glioblastoma) …

Nanoparticle-mediated polycaprolactone based nanofiber mats for enhanced apoptosis of breast cancer cell line with improved cell viability of fibroblast cell line …

E Jaisankar, RS Azarudeen… - Journal of Drug Delivery …, 2023 - Elsevier
Drug loaded nanofiber mats empowered with nanoparticle attracted the clinicians for
profound cancer therapy alongside growth controlling effect towards microbial infections …

Targeted delivery of silibinin via magnetic niosomal nanoparticles: potential application in treatment of colon cancer cells

G Shafiei, D Jafari-Gharabaghlou… - Frontiers in …, 2023 - frontiersin.org
Introduction: In recent years, various nanoparticles (NPs) have been discovered and
synthesized for the targeted therapy of cancer cells. Targeted delivery increases the local …

Effect of dexamethasone-loaded PLGA nanoparticles on oral mucositis induced by 5-fluorouracil

SB Ribeiro, AA de Araújo, MMB Oliveira… - Pharmaceutics, 2021 - mdpi.com
Oral mucositis (OM) is characterized by the presence of severe ulcers in the oral region that
affects patients treated with chemotherapy. It occurs in almost all patients who receive …

Multi-stimuli-responsive nanomicelles fabricated using synthetic polymer polylysine conjugates for tumor microenvironment dependent drug delivery

R Augustine, DK Kim, N Kalva, KH Eom… - Journal of Materials …, 2020 - pubs.rsc.org
A series of multi-stimuli-responsive poly (N-isopropylacrylamide) 30-SS-block-poly (L-lysine)
30-block-poly (caprolactone) n (p (NIPAM) 30-SS-bp (Lys) 30-bp (CL) n)(n= 50, 75, 100 …

Biogenic polymer-encapsulated diosgenin nanoparticles: Biodistribution, pharmacokinetics, cellular internalization, and anticancer potential in breast cancer cells and …

SK Dey, A Pradhan, T Roy, S Das… - Journal of Drug Delivery …, 2022 - Elsevier
Diosgenin (DGN) is a natural bioactive steroidal saponin from therapeutic herbs and it
exhibits potential anticancer efficacy. Here, we report the preparation of poly lactide-co …

Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems

M Rokach, C Portioli, S Brahmachari… - Advanced Drug Delivery …, 2024 - Elsevier
Interest in myelin and its roles in almost all brain functions has been greatly increasing in
recent years, leading to countless new studies on myelination, as a dominant process in the …

Cheilocostus speciosus extract-assisted naringenin-encapsulated poly-ε-caprolactone nanoparticles: Evaluation of anti-proliferative activities

B Rabha, KK Bharadwaj, N Boro, A Ghosh… - Green …, 2021 - pubs.rsc.org
Cheilocostus speciosus (CS) aqueous leaf extract has been used as a biosurfactant in a
simple one-step nano-precipitation method for the synthesis of leaf extract (PE)-mediated …