The management of orofacial pain to alleviate the quality of life of affected patients is
becoming increasingly challenging for scientific research and healthcare professionals …

Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied
by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal …

Neuropathic pain is a chronic pain caused by a disease or damage to the somatosensory
nervous system. The knowledge about the complete mechanisms is incomplete, but the role …

Temporomandibular disorder (TMD) pain that involves inflammation and injury in the
temporomandibular joint (TMJ) and/or masticatory muscle is the most common form of …

Use of chemotherapy drug oxaliplatin is associated with painful peripheral neuropathy that
is exacerbated by cold. Remodeling of ion channels including TRP channels in dorsal root …

Pain is a very important problem of our existence, and the attempt to understand it is one the
oldest challenges in the history of medicine. In this review, we summarize what has been …

Hyperalgesia has become a major problem restricting the clinical application of tooth
bleaching. We hypothesized that transient receptor potential ankyrin 1 (TRPA1), a pain …

Background Orthodontic treatment is the main treatment approach for malocclusion.
Orthodontic pain is an inevitable undesirable adverse reaction during orthodontic treatment …

This study aimed to test for the possible antinociceptive effect of the naturally occurring
terpene citral in rodent models of acute and chronic orofacial pain and to test for the possible …

Obstructive sleep apnea (OSA), characterized by low arterial oxygen saturation during
sleep, is associated with an increased risk of orofacial pain. In this study, we simulated …